461 cases of renal bviopsy specimens were summerized correlated with their light
microscopic and immunofluorescence findings, which obtained from Jan. 1981 to Jul. 1986
at Department of Pathology, Kyung Hee School of Medicine, The results were as
follows:
1) The incidence of IgM nephropathy was about 5.8% of the primary glomerulopathy.
2) Sex distribution showed male preponderance with male: female ratio of 1.7:1.
3) Age distribution were 0-9 years 7.4%, 10-19 years 29.6%, 20-29 years 37.0%, 30-39
years 7.4%, 40-49 years 7.4% and 50-59 years 11.1%.
4) The clinical symptoms were gross hematuria 7.4%, microscopic hematuria 59.2%,
proteinuria (nonnephrotic) 37.0%, nephrotic syndrome 55.5%, hypertension 7.8% and
edema 59.2%.
5) 9 cases (33.3%) had past histories of upper respiratory infections.
6) The distributions of the light microscopic deagnosis were minimal histologic change
11 cases (40.7%), focal glomerulonephritis 7 cases (25.9%), measangial proliferative
glomerulonephritis 5 case (18.5%), focal and segmental glomerulosclerosis 1 case (3.7%)
and poststreptococla glomerulonephritis 1 case (3.7%).
7) Immunofluorescence study showed significant diffuse mesangial granular deposits of
IgM and C3 in all of the 27 cases.
8) It was demonstrated that in the patients with nephrotic syndrome, the prognosis for
the patients with IgM deposition were less favorable than those without IgM deposition.
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